Table 4. Predictors of primary outcomes in Cox regression analysis.

	Univariable		Multivariable
	HR (95% CI)	p value	HR (95% CI)	p value
Early AVR	0.52 (0.29–0.93)	0.028	0.54 (0.30–1.00)	0.049
Age	1.06 (1.02–1.10)	0.004	1.03 (0.98–1.07)	0.242
Sex, male	1.13 (0.64–1.96)	0.816
Body surface area	0.58 (0.11–2.99)	0.514
Body mass index	0.96 (0.89–1.04)	0.325
Hypertension	2.64 (1.34–5.22)	0.005	1.86 (0.86–3.97)	0.110
Diabetes	2.15 (1.21–3.81)	0.009	1.23 (0.63–2.32)	0.515
Atrial fibrillation	2.24 (1.04–4.80)	0.039	1.52 (0.66–3.50)	0.324
Chronic kidney disease	3.63 (2.02–6.53)	<0.001	2.76 (1.50–5.11)	0.001
Coronary artery disease	1.60 (0.77–3.30)	0.209
Aortic valve area	2.28 (0.11–46.5)	0.593
Mean transaortic pressure gradient	0.94 (0.90–1.00)	0.032	0.96 (0.90–1.01)	0.284
Stroke volume index	0.99 (0.96–1.03)	0.662
LV ejection fraction	0.96 (0.94–1.00)	0.053	0.98 (0.95–1.02)	0.404
LV mass index	1.00 (0.99–1.01)	0.825
E/e′ ratio	1.04 (1.01–1.08)	0.021	1.02 (0.98–1.07)	0.285
NYHA class	1.71 (1.07–2.73)	0.024	1.38 (0.85–2.24)	0.191

AVR = aortic valve replacement; CI = confidence interval; HR = hazard ratio; LV = left ventricular; NYHA = New York Heart Association.