Table 3. Effect of time-to-treatment on overall survival in surgically treated clinical stage II patients, depending on their final pathological tumor stage: adjusted hazard ratios for mortality [aHR (95% CI)] calculated by multivariable Cox proportional hazards models.
| Time-to-treatment quartiles | Pathological stage I (N=259) | Pathological stage II (N=763) | Pathological stage III–IV (N=303) | |||||
|---|---|---|---|---|---|---|---|---|
| aHR1 (95% CI) | P value | aHR2 (95% CI) | P value | aHR3 (95% CI) | P value | |||
| Q1 (0–33 d) | Ref | – | Ref | – | Ref | – | ||
| Q2 (34–47 d) | 2.29 (1.08–4.84) | 0.031 | 1.22 (0.86–1.72) | 0.266 | 1.00 (0.63–1.60) | 0.986 | ||
| Q3 (48–64 d) | 2.46 (1.15–5.28) | 0.021 | 1.24 (0.83–1.85) | 0.305 | 1.33 (0.81–2.18) | 0.267 | ||
| Q4 (65–180 d) | 2.77 (1.25–6.15) | 0.012 | 1.32 (0.86–2.03) | 0.201 | 1.20 (0.69–2.08) | 0.515 | ||
| Q2–Q4 (34–180 d) | 2.47 (1.30-4.69) | 0.006 | 1.25 (0.92-1.69) | 0.162 | 1.14 (0.76-1.70) | 0.527 | ||
1, time-to-treatment adjusted for gender; 2, time-to-treatment adjusted for year of incidence, social economic status, age; 3, time-to-treatment adjusted for performance status and histology. aHR, adjusted hazard ratio; CI, confidence interval; d, days.