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. 2023 Nov 16;14:7421. doi: 10.1038/s41467-023-42997-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Candidate associations between prognosis after ICIs treatment and SVs of melanoma patients. Heatmap of correlations between prognosis after ICIs treatment and SVs of A.muciniphila (b) and P.distasonis (c). d Deletion rate across the cohort (y axis) along a genomic region of A.muciniphila (x axis). Spine plots depict the association between response (e), PFS12 (f), and dSVs within each cohort. g Standardized variability (y axis, plotted lines, percentiles 1, 25, 50, 75 and 99) along a genomic region of A.muciniphila (x axis). h Line plots depict the association between PFS12, and vSV within each cohort (h). i Standardized variability (y axis, plotted lines, percentiles 1, 25, 50, 75 and 99) along a genomic region of R.intestinalis (x axis). j Line plots depict the association between response and vSV within each cohort, Q1 to Q4 are defined based on the quantiles of vSV (25%, 50% and 75%). Logistic regression models were performed to calculate beta value (b), ORs and 95% CIs (e, f, h, j) for response and PFS12. Meta-analysis with a random-effect model was performed to integrate the results of different cohorts. Two-sided statistical tests were utilized. No adjustments were made for multiple comparisons. Please also refer to Supplementary Data 4.