Table 2.
Frequencies of Causes of First Recurrence and Death Within 3 Years After Surgery in ICG and Non-ICG Groups
| Events | Surgery, No. (%) | Risk Differencea | Hazard Ratio (95% CI)b | P Valuec | Hazard Ratio (95% CI)d | Adjusted P Valuee | |
|---|---|---|---|---|---|---|---|
| ICG Group (n = 129) | Non-ICG Group (n = 129) | ||||||
| Recurrencef | 23 (17.8) | 40 (31.0) | −0.131 | 0.53 (0.32–0.89) | 0.017 | 0.54 (0.32–0.91) | 0.020 |
| Local | 2 (1.6) | 10 (7.8) | −0.073 | 0.19 (0.04–0.85) | 0.030 | 0.22 (0.05–0.99) | 0.048 |
| Peritoneum | 9 (7.0) | 10 (7.8) | −0.009 | 0.87 (0.35–2.13) | 0.752 | 0.96 (0.39–2.36) | 0.923 |
| Liver | 2 (1.6) | 6 (4.7) | −0.032 | 0.33 (0.07–1.62) | 0.170 | 0.31 (0.06–1.56) | 0.155 |
| Multiple sitesg | 4 (3.1) | 5(3.9) | −0.009 | 0.79 (0.21–2.92) | 0.718 | 0.93 (0.25–3.51) | 0.917 |
| Other or uncertain sitesh | 6 (4.7) | 9 (7.0) | −0.026 | 0.64 (0.23–1.81) | 0.402 | 0.55 (0.19–1.60) | 0.274 |
| All-cause deathi | 18 (14.0) | 34 (26.4) | −0.124 | 0.50 (0.28–0.89) | 0.018 | 0.54 (0.30–0.96) | 0.035 |
| Gastric cancer | 17 (94.4) | 32 (94.1) | −0.116 | 0.50 (0.28–0.91) | 0.022 | 0.53 (0.29–0.96) | 0.037 |
| Other causesj | 1 (5.6) | 2 (5.9) | −0.011 | 0.47 (0.04–5.21) | 0.540 | 0.48 (0.04–5.43) | 0.556 |
aFor recurrence, the risk difference was calculated by subtracting the cumulative incidence in the first 3 years of the Non-ICG group from that of the ICG group, in the presence of competing events; for all-cause death, the risk difference was calculated by subtracting the 3-year overall survival rate of the Non-ICG group from that of the ICG group.
bFor recurrence, competing-risks survival regression was used to derive the hazard ratio, 95% CI, and P value. For total recurrence, all-cause death was the competing event; for the specific types of recurrence, other types of recurrence and death were the competing events; for gastric cancer cause of death, other causes of death were the competing events, and vice versa. Univariable Cox regression was used for recurrence and all-cause death. Non-ICG group is the reference group.
cP value for the hazard ratios.
dMultivariable Cox regression was used for recurrence and all-cause death, adjustment for sex, AJCC7th staging, and adjuvant chemotherapy.
eAdjusted P value for the hazard ratios.
fRefers only to first-time recurrence, even though patients can have recurrence at multiple times.
gIncludes patients who have recurrence simultaneously in 2 or more metastatic sites, including peritoneum, liver, lung, bone, brain, distant lymph node, or other hematogenous metastatic sites.
hIncludes hematogenous recurrence at sites other than the liver (ie, lung, bone, brain, adrenal gland), recurrence at distant lymph node, and recurrence at uncertain sites.
iPost hoc exploratory outcomes. All-cause death includes death from gastric cancer and other causes.
jIncludes other cancers, diseases other than cancer, unintentional injuries, and unknown causes.