Table I.

Top 10 proteins exhibiting increased expression following the development of lenvatinib resistance.

		Expression levelsa		Ratio of expression levelsb
UniProt code	Name	JHH-7	JHH-7_LR	JHH-7_LR/JHH-7	P-valuec
P19022	Cadherin-2	13,995	222,657	15.91	2.4×10−8
P12931	Proto-oncogene tyrosine-protein kinase Src	103,614	563,152	5.44	3.2×10−7
P04179	Superoxide dismutase [Mn], mitochondrial	45,934	226,645	4.93	3.1×10−7
P07305	Histone H1.0	21,414	105,396	4.92	8.5×10−3
P78330	Phosphoserine phosphatase	3,982,655	13,190,082	3.31	10.0×10−8
O43707	α-actinin-4	1,885,027	5,750,919	3.05	7.7×10−6
P35221	Catenin α-1	51,001	150,172	2.94	2.1×10−3
P35222	Catenin β-1	26,094	76,507	2.93	4.8×10−6
Q14651	Plastin-1	97,393	274,947	2.82	3.5×10−6
P08263	Glutathione S-transferase A1	1,866,497	5,041,783	2.70	2.9×10−5

^aAverage total area sums from the peak signals derived from all quantitated peptides in a protein across three replicates.

^bRatio of the average total area sums from JHH-7 and JHH-7_LR samples.

^cP-value was calculated using an unpaired t-test.