Table II.

Top 10 proteins exhibiting decreased expression following the development of lenvatinib resistance.

		Expression levelsa		Ratio of expression levelsb
UniProt code	Name	JHH-7	JHH-7_LR	JHH-7_LR/JHH-7	P-valuec
P15559	NAD(P)H dehydrogenase [quinone] 1	1,145,340	27,193	0.02	4.1×10−5
P21333	Filamin-A	1,611,699	221,586	0.14	4.4×10−6
Q99615	DnaJ homolog subfamily C member 7	323,245	93,505	0.29	2.8×10−6
P11586	C-1-tetrahydrofolate synthase, cytoplasmic	2,096,222	627,168	0.30	1.6×10−8
Q9Y3U8	60S ribosomal protein L36	405,738	121,794	0.30	1.2×10−8
P35579	Myosin-9	773,819	251,904	0.33	9.7×10−4
P18206	Vinculin	1,547,743	505,010	0.33	7.4×10−9
Q13885	Tubulin beta-2A chain	491,799	165,287	0.34	1.7×10−4
Q06830	Peroxiredoxin-1	3,870,952	1,313,386	0.34	5.5×10−5
P15531	Nucleoside diphosphate kinase A	276,722	94,293	0.34	2.7×10−7

^aAverage total area sums from the peak signals derived from all quantitated peptides in a protein across three replicates.

^bRatio of the average total area sums from JHH-7 and JHH-7_LR samples.

^cP-value was calculated using an unpaired t-test.