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. 2023 Oct 19;34:102060. doi: 10.1016/j.omtn.2023.102060

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© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Action potential and calcium handling after exon skipping by Vivo-Morpholinos

(A) SD of the beating interval of spontaneous beating in single-cell analysis (n = 27 and 31, 47, 39, 42 for Δ3–9 hiPSC-CMs and Vivo-S.C. and Vivo-Morpholino-treated Δ3–7 hiPSC-CMs at 1, 2, 4 μM, respectively). (B) APD60 of action potential in monolayered cells at 1/3 Hz pacing (n = 24 and 18, 21, 21, 18 for Δ3–9 hiPSC-CMs and S.C and Vivo-Morpholino-treated Δ3–7 hiPSC-CMs at 1, 2, 4 μM, respectively). (C and D) Time to peak (C) and FWHM (D) of calcium transient in monolayered cells at 1/3 Hz pacing (n = 22 and 20, 22, 20, 19 for Δ3–9 hiPSC-CMs and S.C and Vivo-Morpholino-treated Δ3–7 hiPSC-CMs at 1, 2, 4 μM, respectively). Data are presented as mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.005, ∗∗∗∗p < 0.001.