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. 2023 Oct 20;26(11):108273. doi: 10.1016/j.isci.2023.108273

Figure 5.

Figure 5

WIPF1 regulated genes related to cell proliferation and migration in GC

(A) The heatmap shows the DEGs in MKN45 cells with or without WIPF1 knockdown.

(B) GO analysis of DEGs upon WIPF1 knockdown. The details of this result were demonstrated by the enrichment analysis.

(C) GSEA in MKN45 cells with WIPF1 knockdown. Genes related to signal transduction by a p53 class mediator and an intrinsic apoptotic signaling-mediated pathway by p53 class mediator were enriched for genes highly expressed upon WIPF1 knockdown.

(D) Genes related to the regulation of cell substrate adhesion and extracellular structure organization showed low expression upon WIPF1 knockdown.

(E) The PI3K/AKT signaling pathway was enriched in the WIPF1 regulated function based on TCGA database analysis. Western blot analysis was used to verify that WIPF1 activated the PI3K/AKT signaling pathway.