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. 2023 Nov 16;9:416. doi: 10.1038/s41420-023-01664-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Cells were treated with 4 mM aspirin or control solution for 48 h, then harvested for subsequent western blotting. a Effects of aspirin on the expression of proteins associated with the cell cycle (P21, P27, and the phosphorylation of Rb and CDK2). b Effects of aspirin on the phosphorylation of AKT, MEK, and ERK, which regulated the activities of Ras/Raf/MAPK and PI3K/AKT pathways. c Effects of aspirin on the expression of proteins related to cell metabolism (c-Myc, PKM2 and LDHA). d Effects of aspirin on the phosphorylation of AMPK, 4EBP1 and P70S6K, which related to the activity of AMPK/mTOR pathway. e Effects of aspirin on the expression of COX2 and IL-1β, which related to immunoregulation. Error bars represent the means of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, NS no significance.