Table 1:

Comparison between mutation rates, cumulative stem cell lifetime divisions, hazard ratios for cancer in smokers and mortality rates in smokers and never smokers, for the cancer sites for which information was available in all sources.

Cancer site	Mutation rates in smokersa	Cumulative stem cell lifetime divisionsb	Incidence hazard ratio (relative risk) for smoking menc	Incidence hazard ratio (relative risk) for former smoking menc	Mortality rates smokers with ≥25 cigarettes/day/non-smokersd
Lung adenocarcinoma	150.5	9.272 × 109e	23.30	5.28	415.2 / 16.9
Larynx	137.7	3.186 × 1010f	13.24	3.51	17.3 / 0
Pharynx	38.5	NA	6.67	2.06	19.4 / 0
Bladder	18.3	NA	3.84	2.15	51.4 / 13.7
Esophagus (squamous)	N.S.	1.203 × 109	3.94	1.26	50.0 / 5.7
Liver	6.4	2.709 × 1011	2.92	2.09	31.3 / 4.4
Pancreas adenocarcinoma	N.S.	3.428 × 1011	1.62	0.89	52.9 / 20.6

^aStatistically significant average number of somatic substitutions per genome per pack-year. From Alexandrov et al²⁹

^bCumulative number of divisions of stem cells per lifetime. From Tomasetti and Vogelstein¹

^cFrom Agudo et al¹⁵

^dCumulative mortality rate per 100,000 persons per year, from Doll et al³⁶

^eCumulative number of divisions of stem cells per lifetime. From Tomasetti and Vogelstein¹

^fAdenocarcinoma (same rate in smokers and non-smokers)