Table 2:
Cox Proportional Regression Results of Factors Associated with 5-Year Overall Survival
| Cox Proportional Hazard | ||
|---|---|---|
| HR (95% CI) | p-value | |
| Mental Health Disorder | ||
| No mental health disorder | Ref | Ref |
| Depression Only | 1.37 (1.28 – 1.47) | <0.0001 |
| Anxiety Only | 1.17 (1.06–1.29) | 0.003 |
| Depression and Anxiety | 1.23 (1.08–1.41) | 0.002 |
| Age at Diagnosis, yr | ||
| 67–69 | Ref | Ref |
| 70–74 | 1.35 (1.22–1.49) | <0.0001 |
| 75–79 | 1.62 (1.48–1.79) | <0.0001 |
| 80+ | 2.55 (2.33–2.79) | <0.0001 |
| Sex | ||
| Male | Ref | Ref |
| Female | 0.81 (0.77–0.85) | <0.0001 |
| Race | ||
| White | Ref | Ref |
| Non-White | 0.94 (0.85–1.04) | 0.20 |
| Ethnicity | ||
| Non-Hispanic | Ref | Ref |
| Hispanic | 1.07 (0.95–1.21) | 0.27 |
| Income (census-level) | ||
| <5% below FPL | Ref | Ref |
| 5% to <10% below FPL | 1.07 (1.004–1.13) | 0.03 |
| 10% to <20% below FPL | 1.09 (1.02–1.16) | 0007 |
| 20% to 100% below FPL | 1.07 (0.98–1.17) | 0.11 |
| Unknown | 1.05 (0.95–1.17) | 0.37 |
| Education | ||
| <25% with <12 years of education | Ref | Ref |
| ≥25% with <12 years of education | 1.14 (1.06–1.23) | 0.0005 |
| Marital Status | ||
| Married | Ref | Ref |
| Non-Married/Other | 1.19 (1.14–1.25) | <0.0001 |
| Unknown | 0.88 (0.79–0.98) | 0.02 |
| SEER Registry Region | ||
| Northeast | Ref | Ref |
| Midwest | 1.11 (1.03–1.19) | 0.007 |
| South | 1.10 (1.02–1.19) | 0.02 |
| West | 0.95 (0.90–1.01) | 0.10 |
| Urbanicity | ||
| Metro | Ref | Ref |
| Urban | 1.07 (1.00–1.14) | 0.0504 |
| Rural | 0.90 (0.78–1.05) | 0.18 |
| Charlson Comorbidity Score | ||
| 0 | Ref | Ref |
| 1 | 1.25 (1.19–1.32) | <0.0001 |
| 2+ | 1.80 (1.71–1.89) | <0.0001 |
| Stage | ||
| I | Ref | Ref |
| II | 1.32 (1.23–1.41) | <0.0001 |
| III | 1.49 (1.38–1.61) | <0.0001 |
| IV | 1.66 (1.56–1.78) | <0.0001 |
| Unstaged | 1.27 (1.15–1.40) | <0.0001 |
| Extranodal Involvement | ||
| No | Ref | Ref |
| Yes | 0.99 (0.94–1.04) | 0.69 |
| Year of Diagnosis | ||
| 2001–2003 | Ref | Ref |
| 2004–2007 | 0.78 (0.72–0.85) | <0.0001 |
| 2008–2011 | 0.65 (0.59–0.71) | <0.0001 |
| 2012–2013 | 0.61 (0.56–0.68) | <0.0001 |
| B Symptoms | ||
| Absent | Ref | Ref |
| Present | 1.33 (1.24–1.43) | <0.0001 |
| Unknown | 0.94 (0.87–1.02) | 0.12 |
| NA | 1.03 (0.95–1.11) | 0.48 |
HR: Hazard Ratio (values higher than 1 indicate greater mortality)
FPL: Federal Poverty Level