Figure 3. Genomic Associations of Response and Survival.

A, Mutational frequency plot with each column representing an individual dysplastic sample (sample IDs noted, CT#). Genes are arranged top to bottom by mutational frequency. Tumor mutational burden (TMB) for dysplastic samples is plotted in the bar graph above the mutational plot. Only the top 20 most frequently altered genes are displayed. B, Copy-number alteration plot demonstrating allelic imbalance (amplifications, deletions, or both [polyploidy]) among pretreatment oral dysplastic epithelial samples prior to treatment with 4 doses of nivolumab arranged by those patients who developed oral carcinoma (left) vs not (at last known follow-up).