FIG. 6.

Expression analysis of wild-type IDH2 in glioblastoma. (A) TCGA analysis of wild-type IDH2 expression in normal brain and glioblastoma tumors. *p < 0.05. (B) wild-type IDH2 protein expression in gliomas as a function of tumor grade. Tumors were stained with IDH2-specific antibodies, and staining intensity was quantified by a trained neuropathologist. *p < 0.05. (C) Glioblastoma patient survival as a function of wild-type IDH2 protein expression. Stratification was determined by Cutoff Finder: https://molpathoheidelberg.shinyapps.io/CutoffFinder_v1/. Color images are available online.