Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Summary graphic illustration. Downregulation of mtDNA-encoded LncCytB in diabetes decreases the transcription of CYTB, a gene encoded by mtDNA and critical in the functioning of complex III. The compromised electron transport chain results in increased mitochondrial ROS generation and impaired OCR, and this leads to the development of diabetic retinopathy. LncCytB, long noncoding RNA cytochrome B; mtDNA, mitochondrial DNA; OCR, oxygen consumption rate.
