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. 2023 Nov 3;10:1276588. doi: 10.3389/fvets.2023.1276588

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Copyright © 2023 Stommel, Högler, Mueller, Magnet, Kodajova, Ullram, Szinovatz, Panzer, Engenhart-Seyrl, Kaschmekat, Schütz, Holzer and Weihs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A,B) ECMO set-up in the rat and Timeline of the experimental protocol. (A) Extracorporeal membrane oxygenation (ECMO) circuit consisting of a venous ECMO drainage cannula (1) inserted in the right jugular vein, an open reservoir (2), a roller pump (3), an oxygenator (4) with attached heat exchanger (5) and an arterial ECMO cannula (6) inserted in the right femoral artery. All these elements (custom-made; Dipl.-Ing. Martin Humbs, Valley Germany) were connected by a tubing system with shortcut (7) for priming before resuscitation. Medication was given via left femoral venous cannula (8), invasive blood pressure was measured and blood gas samples collected via left femoral arterial cannula (9). (B) Timeline of the experimental protocol in the 6 min and 8 min cardiac arrest (CA) group; Sevoflurane stop (Sevo. Stop) 1.5 min bevor inducing of ventricular fibrillation (ind VF); Followed by cardiac arrest (CA) for 6 or 8 min; Extracorporeal cardiopulmonary resuscitation (ECPR); heparin (Hep.); epinephrine (EPI.); sodium bicarbonate (Sod. bicarb.); daily scoring of Neurologic Damage Score (NDS) and Overall Performance Category (OPC); sacrification at day 14.