Figure 1.
Existing plasma-based biomarkers to screen MCI and AD patients. Tests with statistically significant outcomes are marked by an asterisk (∗). Significantly lower value of Aβ42/40 ratio was reported in amnestic-MCI patients compared to healthy subjects.2 P-tau 217 refers to phosphorylation of threonine residues at 217 amino acid position. In AD-affected brains, tau protein is present in the form of abnormal neurofibrillary tangles. Autopsy studies from AD-affected brains display a direct correlation between disease severity and tangle deposition.