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. 2023 Oct 11;34(11):1951–2000. doi: 10.1021/acs.bioconjchem.3c00374

Table 4. Highlighted ADC Clinical Trials with Hematological Malignancies Indications in the Development Pipeline.

ADC intervention Sponsor Hematological malignancy indications Target Clinical trial phase NCT number
INA03 INATHERYS Acute Lymphoblastic Leukemia |Acute Myeloid Leukemia CD71 Early Phase I NCT03957915
ABBV-319 AbbVie Diffuse Large B-Cell Lymphoma|Lymphocytic Leukemia|Follicular Lymphoma CD19 Phase I NCT05512390
CC-99712 Celgene Multiple Myeloma BCMA Phase I NCT04036461
CS5001 CStone Pharmaceuticals Advanced Lymphoma PTK7 Phase I NCT05279300
F0002 Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co. CD30+ hematological malignancies CD30 Phase I NCT03894150
JBH492 Novartis Non-Hodgkin’s Lymphoma|Lymphocytic Leukemia CCR7 Phase I NCT04240704
Moxetumomab Pasudotox National Cancer Institute Hairy Cell Leukemia CD22 Phase I NCT03805932
MRG001 Shanghai Miracogen B-cell Non-Hodgkin Lymphoma CD20 Phase I NCT05155839
TRS005 Zhejiang Teruisi Pharmaceutical B-cell Non-Hodgkin’s Lymphoma CD20 Phase I NCT05395533
ADCT-602 ADC Therapeutics Acute Lymphoblastic Leukemia CD22 Phase I |Phase II NCT03698552
BN301 BioNova Pharmaceuticals (Shanghai) Non Hodgkin’s Lymphoma|Diffuse Large B Cell Lymphoma|Follicular Lymphoma CD74 Phase I |Phase II NCT05611853
CX-2029 CytomX Therapeutics Diffuse Large B Cell Lymphoma CD71 Phase I |Phase II NCT03543813
HDP-101 Heidelberg Pharma Multiple Myeloma|Plasma Cell Disorder BCMA Phase I |Phase II NCT04879043
PRO1160 ProfoundBio Non Hodgkin’s Lymphoma CD70 Phase I |Phase II NCT05721222
STI-6129 Sorrento Therapeutics Multiple Myeloma CD38 Phase I |Phase II NCT05308225
Trastuzumab Emtansine National Cancer Institute Advanced Lymphoma|Refractory Plasma Cell Myeloma HER2 Phase II NCT04439110
Zilovertamab vedotin Merck Diffuse Large B-Cell Lymphoma ROR1 Phase II |Phase III NCT05139017
Belantamab mafodotin GlaxoSmithKline Multiple Myeloma BCMA Phase III NCT04162210
Gemtuzumab Ozogamicin Gruppo Italiano Malattie EMatologiche dell’Adulto Acute Myeloid Leukemia CD33 Phase III NCT04168502
Loncastuximab Tesirine ADC Therapeutics Diffuse Large B-Cell Lymphoma CD19 Phase III NCT04384484
Polatuzumab Vedotin Hoffmann-La Roche Diffuse Large B-Cell Lymphoma CD79 Phase III NCT03274492
Brentuximab vedotin Takeda Anaplastic Large-cell Lymphoma CD30 Phase IV NCT01909934
Inotuzumab ozogamicin Pfizer Leukemia| Precursor B-Cell Lymphoblastic Leukemia-Lymphoma CD22 Phase IV NCT03677596