Fig. 1.

Doxorubicin-induced cytotoxicity and cardiomyocyte ferroptosis were relieved by WGX50 in C57BL/6 mice. A Schematic diagram of animal experiments. By Figdraw. B Echocardiographic photographs of M-mode in C57BL/6 mice. C, D Bar charts of left ventricular FS% and EF% in C57BL/6 mice. E Images of HE and Masson-stained mouse myocardium, “_” represents 100 µm. F, G The levels of ANP and BNP in myocardial tissues were detected by RT-qPCR. H–K ELISA kits were used to detect the levels of CK-MB, cTnT, Fe²⁺ and MDA in mice myocardial tissue. L Western blot bands represent GPX4 protein expression in mouse tissues of different groups, and the histogram stands for quantitative data of GPX4 normalized by β-actin. Values are presented as the mean ± SD of three individual experiments (n = 3). *, **, ***, and **** respectively means p < 0.05, p < 0.01, p < 0.001, and p < 0.0001