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. 2023 Nov 17;23:413. doi: 10.1186/s12906-023-04210-6

Table 5.

The central nervous system (CNS) distribution values of the isolated compounds calculated using pkCSM web server

Compound Distribution
BBB permeability (log BB)a CNS permeability (log PS)b
Oleamide (A1) -0.397 -1.651
Stigmasterol (A2) 0.811 -1.033
Deca-2E,4E-dienoic acid 2-phenylethylamide (A3) 0.603 -0.976
Pellitorine (A4) 0.633 1.596
Donepezil 0.157 -1.464

alog BB should be > 0.3 and not less than − 1 for a compound to readily across the BBB

blog PS should be > -2 and not less than − 3 for a compound to penetrate the CNS