Table 2.
Baseline and 12-month data, and change over 12 months in body composition, liver fat on CT, and biochemical parameters
| Baseline measures | P | 12M measures | P | Change over 12 months | Within group change P | Between-group change P | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Surgical (n = 25) | Nonsurgical (n = 27) | Surgical (N = 25) | Nonsurgical (N = 27) | Surgical (N = 25) | Nonsurgical (N = 27) | ||||||
| Body composition and liver fat | |||||||||||
| BMI (kg/m2) | 44.2(41.3, 53.7) | 42.2(38.7, 47.0) | .073 | 31.5(27.8, 36.4) | 41.1(39.0, 47.0) | <.0001 | −12.5 ± .8 | −.2 ± .5 | <.0001 | .963 | <.0001 |
| Weight (kg) | 125.0(111.2, 141.3) | 121.0(102.4, 135.5) | .156 | 89.7(77.1, 108.5) | 122.4(101.9, 136.7) | <.0001 | −34.6 ± 2.4 | .8 ± 1.4 | <.0001 | .474 | <.0001 |
| SAT (cm2) | 700.4 ± 31.2(n = 21) | 695.0 ± 23.9(n = 27) | .892 | 382.6(260.9, 544.4)(n = 22) | 733.6(592.4, 788.4)(n = 26) | <.0001 | −291.4 ± 26.8(n = 21) | 13.6 ± 15.7(n = 26) | <.0001 | .378 | <.0001 |
| VAT (cm2) | 102.0(73.5, 125.6)(n = 21) | 97.1(57.5, 144.6)(n = 27) | .693 | 45.9(31.4, 61.6)(n = 22) | 112.0(74.7, 138.7)(n = 26) | <.0001 | −50.8(−61.3, −34.1)(n = 21) | 13.6(−10.3, 34.8)(n = 26) | <.0001 | .060 | <.0001 |
| Liver/spleen ratio | 1.04(.88, 1.19) | 1.07(.89, 1.22) | .784 | 1.14(1.06, 1.19) | 1.08(.86, 1.18) | .133 | .13 ± .05 | .02 ± .03 | .014 | .861 | .055 |
| Biochemical parameters | |||||||||||
| AST (U/L) | 18.0(13.0, 24.0)(n = 23) | 16.5(14.3, 22.5)(n = 24) | .941 | 13.0(11.3, 16.5)(n = 24) | 17.0(14.5, 22.0)(n = 25) | .010 | −2.0(−9.0; .0)(n = 23) | −1.0(−4.0; 2.0)(n = 23) | .002 | .626 | .082 |
| ALT (U/L) | 12.0(10.0, 22.0)(n = 23) | 13.0(9.5, 17.0)(n = 25) | .555 | 7.0(5.0, 12.3)(n = 24) | 11.5(9.0, 18.3)(n = 26) | .0008 | −5.0(−13.0; −1.0)(n = 23) | −1.0(−2.0; 2.5)(n = 25) | .0003 | .979 | .003 |
| TC (mg/dL) | 151.9 ± 4.7(n = 23) | 147.4 ± 5.9(n = 25) | .560 | 145.7 ± 5.5(n = 24) | 151.4 ± 6.1(n = 26) | .490 | −6.8 ± 4.2(n = 23) | 3.2 ± 4.8(n = 25) | .115 | .515 | .123 |
| HDL (mg/dL) | 44.1 ± 2.3(n = 23) | 44.9 ± 2.1(n = 25) | .788 | 49.9 ± 2.5(n = 24) | 46.1 ± 1.8(n = 26) | .220 | 6.2 ± 1.7(n = 23) | .8 ± 1.4(n = 25) | .001 | .581 | .019 |
| LDL (mg/dL) | 89.7 ± 4.4(n = 23) | 84.0 ± 4.4(n = 25) | .367 | 78.0(62.8, 92.8)(n = 24) | 86.0(65.3, 97.3)(n = 26) | .415 | −11.1 ± 3.3(n = 23) | 2.3 ± 4.2(n = 25) | .002 | .876 | .017 |
| TG (mg/dL) | 91.7 ± 7.7(n = 23) | 95.6 ± 6.6(n = 25) | .708 | 67.5(47.5, 99.0)(n = 24) | 91.0(70.0, 125.0)(n = 26) | .074 | −12.2 ± 5.7(n = 23) | 1.4 ± 6.3(n = 25) | .064 | .886 | .120 |
Abbreviations: ALT, alanine aminotransferase; AST; aspartate aminotransferase; HDL, high-density lipoprotein; LDL, low-density lipoprotein; SAT, subcutaneous adipose tissue; TC, total cholesterol; TG: triglyceride; VAT, visceral adipose tissue.
Data are represented as mean ± standard error of the mean or median (first quartile, third quartile) depending on data distribution. Significant P values are bolded.