Figure 1.

Genes on chromosome 15q11.2-q13 in relation to malignancies. Abbreviations: AS, Angelman syndrome; BP, breakpoint; Cen, centromere; IC, imprinting center; PWS, Prader–Willi syndrome; Tel, telomere. Figure based on Cheon et al (6). Chromosome 15q11.2-q13 can be divided into different regions: a proximal non-imprinted region, the Prader-Willi syndrome (PWS) region that is maternally imprinted, the paternally imprinted region that is also known as the Angelman syndrome region, and a distal non-imprinted region. Legends: Horizontal arrows indicate regions of chromosome 15q11.2-q13 affected by the different genotypes of PWS. Solid horizontal arrows indicate diminished or loss of expression, dotted arrows indicate increased expression. ↑: the gene is upregulated in one or multiple different malignancies in ≥ 80% of studies, ↓: the gene is downregulated in one or multiple different malignancies in ≥ 80% of studies, ↑↓: the gene is more often upregulated than downregulated in one or multiple different malignancies, ↓↑: the gene is more often downregulated than upregulated in one or multiple different malignancies, no symbol: we did not find any information about the relationship between this gene and the development of malignancies.