Skip to main content
. Author manuscript; available in PMC: 2023 Nov 17.
Published in final edited form as: Transl Res. 2020 Oct 10;229:5–23. doi: 10.1016/j.trsl.2020.10.002

Fig. 2. Low concentrations of metformin increase cellular respiration in an AMPK-dependent manner.

Fig. 2.

Exposure to 2.5 μM compound C (Comp C) for 24 h eliminated stimulatory effect of low concentrations (≤ 2.5 mM) of metformin (Metf) on (A) basal, (B) ATP-linked, (C) maximal, and (D) spare capacity oxygen consumption rate (OCR). (E) Effect of metformin (0.5 mM and 10 mM) on phosphorylated AMPK (pAMPK) and total AMPK (tAMPK) expression. (F) Quantitative analysis of pAMPK to tAMPK ratio (one-way ANOVA and post-hoc Tukey test). Data are expressed as mean ± SD; * p < 0.05 compared to non-compound c (no Comp C); n=3.