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. 2022 Oct 31;15(10):dmm049492. doi: 10.1242/dmm.049492

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Metabolite set enrichment analysis (MESA) and shared deregulated pathways. (A) Yeast metabolomics (present study) show significantly different levels of metabolites in yeasts 46Q, 72Q and 103Q compared to 25Q. (B) MSEA showing shared pathways deregulated in 25Q vs 46Q, 25Q vs 72Q and 25Q vs 103Q. (C) Metabolomics pathway overlaps determined in our study (yeasts 25Q vs 46Q, 25Q vs 72Q and 25Q vs 103Q) and literature show pathways commonly deregulated in yeast 103Q compared to yeast 25Q. (D,E) Comparative analysis of significantly enriched metabolic pathways identified in a HD mouse model (D) and in HD patients (E). (F) Metabolomics of previously published deregulated metabolic pathways in human (literature) and deregulated pathways identified in our HD patient cohort (present study), showing an overlap of three deregulated pathways. (G) Plotted is the overlap of deregulated metabolic pathways identified in yeast and mouse HD models, and HD patients. BS, brain stem; CB, cerebellum; CSF, cerebrospinal fluid; CT, cortex; FL, frontal lobe; ST, striatum.