TABLE 1.
Ingenuity Canonical Pathways identified by IPA analysis in differentially expressed genes between SRC-2f/f and SRC-2d/d mouse uteri at GD5
| Ingenuity Canonical Pathways | p- value | Z-Score | Molecules |
|---|---|---|---|
| Regulation Of The Epithelial Mesenchymal Transition In Development Pathway | 6.46E-04 | −2.529822128 | BCL9,CDH1,FZD1,FZD9,GLIS1,HNF1A,LEF1,mir-8,REL,SNAI1,WNT2,WNT6,WNT7B |
| Antioxidant Action of Vitamin C | 1.05E-04 | −2.496150883 | GSTO1,JAK2,MAPK11,MAPK13,NFKBIA,NOTUM,PLA2G10,PLA2G2D,PLA2G2E,PLA2G4F,PLA2G5,PLB1,PLCH1,PLCH2,REL,SLC23A3, STAT5A |
| Basal Cell Carcinoma Signaling | 1.38E-03 | −2.121320344 | BMP2,BMP5,BMP8A,FZD1,FZD9,GLIS1,HNF1A,LEF1,WNT2,WNT6,WNT7B |
| BEX2 Signaling Pathway | 1.23E-03 | −2.110579412 | HNF1A,ITGB6,KLK3,LEF1,MMP2,NFKBIA,PDGFC,PGF,PPP2R2B,PPP2R2C,REL,SPP1 |
| Pulmonary Healing Signaling Pathway | 1.48E-04 | −2.041241452 | BMPR1B,CDH1,DLK1,FGFR1,FRK,FZD1,FZD9,HNF1A,LEF1,MAPK11,MAPK13,MMP2,MMP3,NFKBIA,NOTCH4,PDGFC,PGF,PRKCG, RASD1,SMAD9, STAT5A,WNT2,WNT6,WNT7B |
| Colorectal Cancer Metastasis Signaling | 1.29E-03 | −1.963961012 | ADCY2,CDH1,DCC,FZD1,FZD9,GNG12,GNG4,HNF1A,JAK2,LEF1,MMP2,MMP3,NOS2,PDGFC,PGF,PIK3C2G,PIK3R3,RAC3,RASD1,REL, RHOBTB2, RHOV, TLR1,Tlr12,WNT2,WNT6,WNT7B |
| S100 Family Signaling Pathway | 1.29E-10 | −1.843908891 | ADCYAP1R1,ADGRA1,ADGRF1,ADGRG7,ADGRV1,ADORA1,ADORA2B,ADRA1A,ADRA1B,ADRA1D,ADRA2B,ANXA1,BDNF,BTC, CACNA1B, CACNA2D3,CDH1,CELSR1,CELSR2,CTSD,DRD4,EDNRB,EREG,ESR2,ETV4,F2R,F2RL3, FGFR1,FGFR3,FZD1,FZD9,GALR3, GPR160,GPRC5A,GPRC5C,HCAR2,HNF1A,HTR1D,HTR6,IFNK,Ighg2b,KLK3,LEF1,LPAR3,MAPK11,MAPK13,MMP2,MMP3,NAPSA,NMUR2, NOS2,NOTUM,NPY2R,OXTR,P2RY14, PDGFC,PGF,PIK3C2G, PIK3R3,PLA2G10,PLA2G2D,PLA2G2E,PLA2G4F,PLA2G5,PLCH1,PLCH2, PRKCG,PTGDR,PTGIR,RAC3,RXFP1,S100A14,S100A3, S100A6,S100A8,S1PR3,SMAD6,SMAD9,TACR1,TRPV5,VDR,VIPR2,WNT2,WNT6, WNT7B |
| Factors Promoting Cardiogenesis in Vertebrates | 1.29E-03 | −1.414213562 | BMP2,BMP5,BMP8A,BMPR1B,FZD1,FZD9,HNF1A,LEF1,NOG,NOTUM,NPPA,PLCH1,PLCH2,PRKCG,SMAD9,WNT2,WNT6,WNT7B |
| Pulmonary Fibrosis Idiopathic Signaling Pathway | 2.69E-05 | −1.333333333 | CDH1,COL13A1,COL22A1,COL25A1,COL26A1,Col6a4,COL6A5,COL6A6,EFNB2,F2R,FGF18,FGFR1,FGFR3,FZD1,FZD9,HNF1A,IL11, IL13RA1,ITGB6,JAK2, LEF1,MAPK11,MAPK13,MMP2,MMP3,NOTCH4,PDGFC,PIK3C2G,PIK3R3,PLAU, RASD1,REL,SNAI1,WNT2,WNT6, WNT7B |
| WNT/β-catenin Signaling | 5.50E-06 | −1.091089451 | BCL9,CDH1,CDH5,CDKN2A,DKK3,DKKL1,FRZB,FZD1,FZD9,GJA1,HNF1A,KREMEN2,LEF1,PPP2R2B,PPP2R2C,RARB,SFRP1,SFRP2, SFRP4,SFRP5,SOX7, SOX9,WNT2,WNT6,WNT7B |