Fig 3. True positive rate for detecting mediation signals at a false discovery rate of 10%.

Value shown is the mean TPR across 100 simulated data replicates, with intervals representing the inner 95% range. False discovery proportion was capped below 10% by a proper choice of the p-value threshold (one-at-a-time, HIMA, HDMA, MedFix), posterior inclusion probability threshold (BSLMM), or tuning parameter (pathway LASSO).