Table 4.
Predictors of 21-day transplant-free survival in APAP-ALF patients.
| Variable | Univariate | |||
|---|---|---|---|---|
| N | OR | 95% OR CI | P-value | |
| Sex a | 1069 | 0.92 | (0.69, 1.24) | 0.60 |
| Age | 1069 | 0.99 | (0.98, 1.00) | 0.046 |
| Vasopressors (days 1–7) | 1069 | 0.13 | (0.09, 0.17) | <0.001 |
| CRRTb (days 1–7) | 1069 | 0.58 | (0.42, 0.81) | 0.001 |
| Grade 3/4 Coma (days 1–7) | 1038 | 0.10 | (0.07, 0.15) | <0.001 |
| King’s College Criteria (days 1–7) | 1069 | 0.23 | (0.17, 0.32) | <0.001 |
| Highest MELD Score (days 1–7) | 1058 | 0.91 | (0.89, 0.92) | <0.001 |
| Overdose Intent c | 956 | 1.08 | (0.82, 1.42) | 0.58 |
| Psych Comorbidity | 1069 | 1.15 | (0.89, 1.48) | 0.28 |
| Time Cohort d | 1069 | 1.44 | (1.12, 1.85) | 0.005 |
| Variable | Multivariate Model 1 N = 1028 AUROC = 0.86 | |||
| Included in Model | aOR | 95% aOR CI | P-value | |
| Sex a | No | -- | -- | -- |
| Age | Yes | 0.99 | (0.98,1.00) | 0.10 |
| Vasopressors (days 1–7) | Yes | 0.25 | (0.17, 0.35) | <0.001 |
| CRRTb (days 1–7) | Yes | 1.62 | (1.07, 2.44) | 0.023 |
| Grade 3/4 Coma (days 1–7) | Yes | 0.21 | (0.13, 0.33) | <0.001 |
| King’s College Criteria (days 1–7) | Yes | 0.53 | (0.36, 0.78) | 0.001 |
| Highest MELD Score (days 1–7) | Yes | 0.92 | (0.90, 0.94) | <0.001 |
| Overdose Intent c | No | -- | -- | -- |
| Psych Comorbidity | No | -- | -- | -- |
| Time Cohort d | Noe | -- | -- | -- |
| Variable | Multivariate Model 2 N = 1028 AUROC = 0.86 | |||
| Included in Model | aOR | 95% aOR CI | P-value | |
| Sex a | No | -- | -- | -- |
| Age | Yes | 0.99 | (0.98, 1.00) | 0.06 |
| Vasopressors (days 1–7) | Yes | 0.28 | (0.20, 0.39) | <0.001 |
| CRRTb (days 1–7) | Noe | -- | -- | -- |
| Grade 3/4 Coma (days 1–7) | Yes | 0.21 | (0.13, 0.33) | <0.001 |
| King’s College Criteria (days 1–7) | Yes | 0.53 | (0.36, 0.79) | 0.002 |
| Highest MELD Score (days 1–7) | Yes | 0.92 | (0.90, 0.94) | <0.001 |
| Overdose Intent c | No | -- | -- | -- |
| Psych Comorbidity | No | -- | -- | -- |
| Time Cohort d | Yes | 1.42 | (1.03, 1.97) | 0.034 |
a
Reference group: male sex
b
Reference group: receipt of intermittent hemodialysis only or no renal replacement therapy
c
Reference group: unintentional overdose
d
Reference group: 1998–2007 enrollment cohort
e
Use of CRRT (Model 1) and enrollment time cohort (Model 2) were evaluated in separate models
Abbreviations: (a)OR, (adjusted) odds ratio; AUROC, area under receiver operator curve; CI, confidence interval; CRRT, continuous renal replacement therapy; MELD, model for end stage liver disease.