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. Author manuscript; available in PMC: 2023 Nov 17.
Published in final edited form as: Clin Gastroenterol Hepatol. 2020 Sep 10;19(12):2615–2625.e3. doi: 10.1016/j.cgh.2020.09.016

Table 4.

Predictors of 21-day transplant-free survival in APAP-ALF patients.

Variable Univariate
N OR 95% OR CI P-value
Sex a 1069 0.92 (0.69, 1.24) 0.60
Age 1069 0.99 (0.98, 1.00) 0.046
Vasopressors (days 1–7) 1069 0.13 (0.09, 0.17) <0.001
CRRTb (days 1–7) 1069 0.58 (0.42, 0.81) 0.001
Grade 3/4 Coma (days 1–7) 1038 0.10 (0.07, 0.15) <0.001
King’s College Criteria (days 1–7) 1069 0.23 (0.17, 0.32) <0.001
Highest MELD Score (days 1–7) 1058 0.91 (0.89, 0.92) <0.001
Overdose Intent c 956 1.08 (0.82, 1.42) 0.58
Psych Comorbidity 1069 1.15 (0.89, 1.48) 0.28
Time Cohort d 1069 1.44 (1.12, 1.85) 0.005
Variable Multivariate Model 1 N = 1028 AUROC = 0.86
Included in Model aOR 95% aOR CI P-value
Sex a No -- -- --
Age Yes 0.99 (0.98,1.00) 0.10
Vasopressors (days 1–7) Yes 0.25 (0.17, 0.35) <0.001
CRRTb (days 1–7) Yes 1.62 (1.07, 2.44) 0.023
Grade 3/4 Coma (days 1–7) Yes 0.21 (0.13, 0.33) <0.001
King’s College Criteria (days 1–7) Yes 0.53 (0.36, 0.78) 0.001
Highest MELD Score (days 1–7) Yes 0.92 (0.90, 0.94) <0.001
Overdose Intent c No -- -- --
Psych Comorbidity No -- -- --
Time Cohort d Noe -- -- --
Variable Multivariate Model 2 N = 1028 AUROC = 0.86
Included in Model aOR 95% aOR CI P-value
Sex a No -- -- --
Age Yes 0.99 (0.98, 1.00) 0.06
Vasopressors (days 1–7) Yes 0.28 (0.20, 0.39) <0.001
CRRTb (days 1–7) Noe -- -- --
Grade 3/4 Coma (days 1–7) Yes 0.21 (0.13, 0.33) <0.001
King’s College Criteria (days 1–7) Yes 0.53 (0.36, 0.79) 0.002
Highest MELD Score (days 1–7) Yes 0.92 (0.90, 0.94) <0.001
Overdose Intent c No -- -- --
Psych Comorbidity No -- -- --
Time Cohort d Yes 1.42 (1.03, 1.97) 0.034
a

Reference group: male sex

b

Reference group: receipt of intermittent hemodialysis only or no renal replacement therapy

c

Reference group: unintentional overdose

d

Reference group: 1998–2007 enrollment cohort

e

Use of CRRT (Model 1) and enrollment time cohort (Model 2) were evaluated in separate models

Abbreviations: (a)OR, (adjusted) odds ratio; AUROC, area under receiver operator curve; CI, confidence interval; CRRT, continuous renal replacement therapy; MELD, model for end stage liver disease.