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. 2023 Oct 19;26(11):108279. doi: 10.1016/j.isci.2023.108279

Figure 6.

Figure 6

ILA affects ILC3 responses via the AhR signaling

(A) Fold change in Il22 mRNA expression in isolated ILC3s stimulated with ILA at 5, 50, 100 and 200 μM as compared with vehicle (DMSO control) (n = 3 per group).

(B) Fold changes over vehicle (DMSO control) in Il22 mRNA expression in isolated ILC3s in the presence of 200 μM ILA with or without the AhR antagonist CH-223191 (n = 6 per group).

(C) ELISA determined the protein levels of IL-22 in isolated ILC3s in the presence of vehicle alone (DMSO) or 200 μM ILA with or without the AhR antagonist CH-223191 (n = 6 per group).

(D–F) Fold changes over vehicle (DMSO control) in Cyp1a1 (D), Fmo2 (E) and Kit (F) mRNA expression in isolated ILC3s in the presence of 200 μM ILA with or without the AhR antagonist CH-223191 (n = 6 per group).

Data shown as the mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001.