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. 2023 Oct 16;42(47):3514–3528. doi: 10.1038/s41388-023-02858-5

Fig. 1. KLHL29 is downregulated in TNBC, and its downregulation is associated with unfavorable prognosis.

Fig. 1

A mRNA expression levels of KLHL29 in 360 TNBC tissues and 88 adjacent normal tissues in FUSCC-TNBC RNA-seq dataset. B mRNA expression levels of KLHL29 in 88 TNBC tissues and paired adjacent normal breast tissues in FUSCC-TNBC RNA-seq dataset. C mRNA expression levels of KLHL29 in 169 TNBC tissues and 113 adjacent normal tissues in TCGA TNBC RNA-seq dataset. D mRNA expression levels of KLHL29 in 13 TNBC tissues and paired adjacent normal breast tissues in TCGA TNBC RNA-seq dataset. Data are represented as mean ± SD. Wilcoxon rank-sum test. E–H Kaplan–Meier plots of KLHL29 in basal-like breast cancer according to PAM50 and St Gallen subtypes (https://kmplot.com/analysis/). Log-rank test. I Immunohistochemical staining analysis of KLHL29 expression in TNBC specimens. Representative images are shown. J, K Low expression level of KLHL29 is associated with poor overall survival (J) and relapse-free survival (K) Log-rank test.