Table 2.

PolyP-driven thrombin generation of functionalized silk fibroin membranes

	Plasma with buffer (PPP)	Silk control	µg/mm2 silk + polyP
			2	6	20	60	200	600	2000
ETP (nM⋅min)	519.2 ± 413	955.5 ± 119	970.6 ± 170	1098 ± 310	1279.9 ± 183	1391.2 ± 160	1525.7 ± 227	1339.3 ± 9	−1
Peak thrombin (nM)	52.3 ± 50	198.4 ± 70	175.9 ± 53	207.8 ± 119	246.2 ± 51	267.3 ± 38	310.1 ± 27	243.4 ± 56	−1
Time to peak (min)	28.8 ± 7	15.3 ± 1.4	17.1 ± 5	13.1 ± 6	11.8 ± 1.8	10.2 ± 0.5	9.8 ± 0.7	8.9 ± 0.6	−1
Lag time (min)	23.3 ± 6	12.8 ± 0.7	14 ± 4	10 ± 4	9.1 ± 1.5	7.4 ± 0.1	7.6 ± 0.6	6.8 ± 0.4	−1

Comparison of thrombin formation in normal platelet-poor plasma, silk fibroin membrane-induced plasma and polyP-coated silk fibroin membrane-induced plasma

PPP, platelet-poor plasma; silk + polyP, 3 × 3 mm silk fibroin membranes coated with polyp

Values are expressed as mean ± SD, n = 2 in duplicates