Table 1.
Characteristics of the patients according to the success or failure of isolated oocyte retrieval and the source of the oocytes (antral follicles or preparation medium) retrieved during ovarian tissue cryopreservation
| Study parameters | General population | Oocytes collected | No oocytes collected | Oocytes collected from follicles | No oocytes collected from follicles | Oocytes collected from medium | No oocytes collected from medium |
|---|---|---|---|---|---|---|---|
| Patients n (%) | 257 (100) | 121 (47.1) | 136 (52.9) | 45 (17.5) | 212 (82.5) | 115 (44.7) | 142 (55.3) |
| Median age at OTC [range] | 17.1 [0.3–38.3] | 19.8a [0.3–38.3] | 15.6a [0.6–36.6] | 22.8b [4.0–34.8] | 15.6b [0.3–38.3] | 19.0 [0.3–38.3] | 15.9 [0.6–36.6] |
| Ovarian status at OTC n (%) | |||||||
| Prepubescent | 96(37.4) | 41 (42.7)b | 55 (57.3) b | 9 (20.0)b | 87 (41.0)b | 41 (35.6) | 55 (38.7) |
| Post-pubescent | 161 (62.6) | 80 (49.7) | 81 (50.3) | 36 (22.4)b | 125 (77.6)b | 74 (46.0) | 87 (54.0) |
| Post-pubescent without cycle | 88 (34.2) | 34 (38.6)b | 54 (61.4)b | 12 (26.7)b | 76 (35.9)b | 30 (26.1)b | 58 (40.9)b |
| Post-pubescent with cycles | 73 (28.4) | 46 (63.0)b | 27 (37.0)b | 24 (53.3)b | 49 (23.1)b | 44 (38.3)b | 29 (20.4)b |
| Prior chemotherapy n (%) | |||||||
| No | 127 (49.4) | 78 (61.4)c | 49 (38.6)c | 30 (23.6)a | 97 (76.4)a | 75 (59.1)c | 52 (40.9)c |
| Yes | 130 (50.6) | 43 (33.1)c | 87 (66.9)c | 15 (11.5)a | 115 (88.5)a | 40 (30.8)c | 90 ( 69.2)c |
| Yes, without alkylating agents | 68 (26.5) | 33 (48.5) | 35 (51.5) | 11 (16.2) | 57 (83.8) | 31 (45.6)c | 37 (54.4)c |
| Yes, with alkylating agents | 62 (24.1) | 10 (16.1)c | 52 (83.9)c | 4 (6.4) | 58 (93.6) | 9 (14.5)c | 53 (85.5)c |
| Diseases n (%) | |||||||
| Non-malignant diseases** | 40 (15.6) | 31 (77.5)c | 9 (22.5) c | 10 (25.0) | 30 (75.0) | 30 (75.0) c | 10 (25.0)c |
| Hematological malignancies | 89 (34.6) | 43 (48.3) | 46 (51.7) | 17 (19.1) | 72 (80.9) | 39 (43.8) | 50 (56.2) |
| Solid tumors | 100 (38.9) | 40 (40.0) | 60 (60.0) | 16 (16.0) | 84 (84.0) | 39 (39.0) | 61 (61.0) |
| Turner syndrome | 28 (10.9) | 7 (25.0)a | 21 (75.0)a | 2 (7.1) | 26 (92.9) | 7 (25.0)a | 21 (75.0)a |
Statistical comparisons (oocytes vs. no oocytes collected, oocytes vs. no oocytes collected from follicles, oocytes vs. no oocytes collected from medium): a: P <.05 and ≥.01, b: P <.01 and ≥.001, c: P<.001
**Non-malignant diseases other than Turner syndrome