Fig. 6.

Current model for the C. elegans endoderm GRN. Solid lines indicate known interactions identified biochemically or implied genetically, whereas dashed lines represent proposed interactions. SKN-1 initiates the GATA-driven cascade. END-1 and END-3 are also regulated by non-GATA TFs, including SPTF-3 (Sullivan-Brown et al., 2016), PAL-1 (Maduro et al., 2005b), PLP-1 (Witze et al., 2009) and POP-1 (Maduro et al., 2005b), which are omitted from this model for simplicity. See text for details.