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. 2023 Nov 17;14:7473. doi: 10.1038/s41467-023-43038-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a CD8 T cells and expression of their canonical markers. b GO term enrichment of upregulated genes in CD8-VHHs library injected mice in CD8 T cells were performed using enricher package, significance was determined by Fisher exact test (−log10) of adjusted p value by benjamini-hochberg (BH) method. c UMAP plot showing the CD8 sub-populations by sub-clustering CD8 T cells. Black arrows refer to sub-population cluster 5. d Histogram showing relative distribution of CD8+ T cell sub-populations based upon sample type. e Heatmap showing naïve markers, immune checkpoint, cytokines and effector molecules, co-stimulatory molecules, and transcriptional factor genes expression in CD8 T cells sub-populations and injected libraries. f GO term enrichment of upregulated genes in CD8-VHHs library injected mice in CD8 T cells cluster 5, enrichment was performed using enricher package, significance was determined by Fisher exact test (−log10) of adjusted p value by benjamini-hochberg (BH) method. Source data are provided as a Source Data file.