Table 1.
Baseline demographic and clinical characteristics.
| Liver failure | p-value | |||
|---|---|---|---|---|
| Yes (62) | No (138) | Total (200) | ||
| Male sex | 35 (56.5) | 90 (65.2) | 125 (62.5) | 0.236 |
| Age (median, years) | 60.5 (51.8–66.3) | 70 (57.8–82) | 66 (55–78) | < 0.001 |
| White ethnicity | 52 (83.9) | 126 (91.3) | 178 (89) | 0.120 |
| SAPS-3 (at ICU admission) | 60 (48.5–72) | 63 (55.75–77) | 62 (51–75) | 0.10 |
| SOFA | ||||
| First CVVHDF day | 15 (13–17) | 12.5 (19.75–14) | 13 (11–15) | < 0.001 |
| Second CVVHDF day | 16 (13–17) | 12 (10–14) | 13 (11–15) | < 0.001 |
| Third CVVHDF day | 16 (13–17) | 12 (10–14) | 13 (11–15) | < 0.001 |
| Fourth CVVHDF day | 15 (13–17) | 12 (9–14) | 13(10–15) | < 0.001 |
| Fifth CVVHDF day | 16 (14–18) | 11 (9–14) | 13 (10–16) | < 0.001 |
| Sixth CVVHDF day | 15 (14–17) | 11(8–14) | 13(10–15) | < 0.001 |
| Seventh CVVHDF day | 16 (14–17) | 11 (9–14) | 13(10–16) | < 0.001 |
| Comorbidities | ||||
| CKD on dialysis | 5 (8.1) | 12 (8.7) | 17 (8.5) | 0.882 |
| Systemic arterial hypertension | 13 (21) | 54 (39.1) | 67 (33.5) | 0.015 |
| Diabetes mellitus | 13 (21) | 38 (27.5) | 51 (25.5) | 0.382 |
| Chronic obstructive pulmonary disease | 4 (6.5) | 20 (14.5) | 24 (12) | 0.157 |
| Solid malignant tumor | 7 (11.3) | 22 (15.9) | 29 (14.5) | 0.516 |
| Hematological cancer | 4 (6.5) | 22 (15.9) | 26 (13) | 0.072 |
| HSCT | 1 (1.6) | 9 (6.5) | 10 (5) | 0.178 |
| Cirrhosis | 28 (45.2) | 14 (10.1) | 42 (21) | < 0.001 |
| Solid organ transplant | ||||
| Liver | 16 (25.8) | 19 (13.8) | 35 (17.5) | 0.038 |
| Heart | 1 (1.6) | 2 (1.4) | 3 (1.5) | 0.930 |
| Kidney | 1 (1.6) | 6 (4.3) | 7 (3.5) | 0.440 |
| Reason for admission to the ICU | ||||
| Sepsis | 31 (50) | 82 (59.4) | 113 (56.5) | 0.214 |
| Liver failure | 9 (14.5) | 4 (2.9) | 13 (6.5) | 0.002 |
| Heart failure | 2 (3.2) | 10 (7.2) | 12 (6) | 0.349 |
| Solid organ transplant | 10 (16.1) | 11 (8) | 21 (10.5) | 0.082 |
| Elective surgery | 3 (4.8) | 10 (7.2) | 13 (6.5) | 0.523 |
| Emergency surgery | 4 (6.5) | 16 (11.6) | 20 (10) | 0.262 |
| Vasoactive drug use | 54 (87.1) | 115 (83.3) | 169 (84.5) | 0.496 |
| Mechanical ventilation | 53 (85.5) | 105 (76.1) | 158 (79) | 0.131 |
| Sedation | 50 (80.6) | 98 (71) | 148 (74) | 0.151 |
| Causes of liver failure | ||||
| Multiple organ dysfunction | 17 (27.4) | – | – | – |
| Cirrhosis | 32 (51.6) | – | – | – |
| Related to liver transplant | 13 (20.9) | – | – | – |
ICU, intensive care unit; SAPS, Simplified Acute Physiology Score; SOFA, Sequential Organ Failure Assessment; CCVVHDF, continuous venovenous hemodiafiltration; CKD, chronic kidney disease; HSCT, hematopoietic stem cell transplantation.