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. 2023 Nov 17;14:7457. doi: 10.1038/s41467-023-42550-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Statistical significance of the identified number of SC-DRMs associated with each drug. The p-value measures the probability of observing by a random chance at least the observed number of SC-DRMs among all DRMs associated with a drug (one-sided test; see “Methods” section for details). Results with p-value < 0.05 are marked with a star on the top of each bar. Source data and exact p-values are provided as a Source Data file.