Table 1.
CAR-NK platforms to target liquid tumors.
| Type of Cancer | Target Antigen | Intracellular Domain | References |
|---|---|---|---|
| MM | CD138 | CD3ζ | (37) |
| MM | CS1 | CD28-CD3ζ | (38) |
| MM | NKG2D | 4-1BB-CD3ζ | (39) |
| MM | BCMA | 2B4-CD3ζ | (40, 41) |
| MM | BCMA | unknown | (42) |
| MM | BCMA GPRC5D |
unknown | (31) |
| MM | GPRC5D CD38 |
unknown | (43) |
| MM | BCMA | unknown | (44) |
| T-ALL | CD5 | CD28-4-1BB-CD3ζ | (45) |
| B cell lymphoma | CD19 | CD28-4-1BB-CD3ζ | (46) |
| B-ALL | CD19 | 4-1BB-CD3ζ | (47) |
| B-ALL | CD19 | CD28-CD3ζ | (48) |
| B-cell leukemia | CD19 | CD28-CD3ζ 4-1BB-CD3ζ |
(49) |
| B-ALL | CD19 | 4-1BB-CD3ζ | (50) |
| B-ALL | CD19 | CD28-CD3ζ | (51) |
| B-lineage leukemia | CD19 | CD3ζ | (52) |
| B-ALL | FLT3 | CD28-CD3ζ | (53) |
| CLL | CD19 | CD28-CD3ζ-IL15 | (54) |
| B-NHL | CD20 | 4-1BB-CD3ζ | (55) |
| Burkitt lymphoma | CD20 | 4-1BB-CD3ζ | (56) |
| Burkitt lymphoma | CD38 | CD28-4-1BB-CD3ζ | (57) |
| NHL | CD4 | CD28-4-1BB-CD3ζ | (58) |