Table 2.
Genes suppressed by Brazilian green propolis treatment in the prefrontal cortex
| Gene Symbol | Gene Accession | Value (Log2 Ratio) | Log Ratio 1) | p-value 1) | Log Ratio 2) | p-value 2) | ||
|---|---|---|---|---|---|---|---|---|
| Sham | Aβ | Aβ + PP900 | ||||||
| Trem2 | NM_001272078 | 6.8 | 7.8 | 6.9 | 0.97 | 0.011 | ‒0.85 | 0.019 |
| Gbp3 | NM_001289492 | 5.2 | 6.0 | 5.6 | 0.87 | 0.00 | ‒0.44 | 0.036 |
1) Log ratio between the sham and Aβ groups, p-value determined using Student’s t-test
2) Log ratio between the Aβ and Aβ + PP900 groups, p-value determined using Student’s t-test
Sham group [sham operation plus vehicle (0.5% methylcellulose) treatment]; Aβ group (ICV Aβ25‒35 injection plus vehicle treatment); Aβ + PP900 group (ICV Aβ25‒35 injection plus 900 mg/kg b.w. Brazilian green propolis)