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. 2023 Sep 18;51(5):1749–1763. doi: 10.1042/BST20210567

Figure 5. Histone mutations may alter chromatin structure and function by diverse mechanisms.

Figure 5.

(A) Histone mutations that affect sites of post-translational modification can block epigenetic writers such as PRC2, resulting in a redistribution of epigenetic marks that regulate gene expression. HMT, Histone methyltransferase; PRC2, Polycomb repressive complex 2. (B) Histone mutations that disrupt intra-nucleosomal histone interactions may destabilize the nucleosome, alleviating nucleosome mediated gene repression. (C) Histone mutations that affect the acid patch may disrupt other proteins from binding to the nucleosome. (D) Mutation of histone H1 can block both association of H1 with chromatin and chromatin compaction, changing chromatin accessibility.