Table 3.
Anti-Inflammatory Activity of 80% Methanol Extracts of Premna Schimperi on Exudate and Granuloma Tissue Formation in Cotton Pellet-Induced Granuloma in Rats
| Group & Dose | Exudates (mg) M ± SEM and Intergroup Comparison | [%A] of Exudate Inhibition | Granuloma (mg) M ± SEM and Intergroup Comparison | [%A] of Granuloma Inhibition |
|---|---|---|---|---|
| Tw80 | 153.23±1.47 | – | 39.18±1.25 | – |
| Indo10 | 78.27±3.22AcCcDb | 48.92 | 15.04±0.70AcCcDc | 61.61 |
| PS200 | 96.16±2.29AcBc | 37.25 | 26.11±1.03AcBc | 33.37 |
| PS400 | 88.58±1.59AcBb | 42.19 | 23.95±1.67AcBcEa | 38.88 |
| PS800 | 81.10±3.25AcCc | 47.08 | 18.24±1.35AcCc | 53.45 |
Notes: The data are presented as mean ± SEM (n=6) and analyzed using a one-way ANOVA with a Tukey post hoc test; ACompared to Tw80; BCompared to Indo10; CCompared to PS200; DCompared to PS400; ECompared to PS800; aP<0.05, bP<0.01, cP<0.001.
Abbreviations: %A, percent inhibition of wet excaudate and granuloma tissue formation; Indo10, Indomethacin 10 mg/kg; PS, Premna Schimperi extracts; TW80, 2% Tween 80; M ± SEM, mean ± standard error of mean.