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Effect of histone deacetylase inhibitors on rrf-3; elt-2::gfp silencing at 16°C
| GFP expression | No HDAC inhibitor | TSA (4 μM) | Apicidin (2 μM) | n-butyrate (6.7 mM) |
|---|---|---|---|---|
| Expression in more than 5 nuclei | 2/40a (5%) | 26/41 (63%) | 21/42 (50%) | 32/40 (80%) |
| Complete silencing | 15/40 (38%) | 0/41 (0%) | 1/42 (2%) | 0/40 (0%) |
Fraction of worms showing phenotype of a total number scored.
