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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Ann Neurol. 2023 Jun 14;94(3):442–456. doi: 10.1002/ana.26710

Figure 6: Glymphatic gradient and the relationship between different regional glymphatic functions.

Figure 6:

(A-B) show the DTI-ALPS gradient and inter-group differences. (C-D) show the paired-sample t-test between aDTI-ALPS and pDTI-ALPS, and aBOLD-CSF coupling and pBOLD-CSF coupling, respectively. (E) Heatmaps show the relationship between glymphatic measures in the whole cohort and in the groups separately. P values in heatmaps were adjusted for age, sex, scanning sites (right), and groups (left). bvFTD = behavioral variant frontotemporal dementia; HCs = healthy controls. CP = choroid plexus; ICV = intracranial volume; g/a/m/pDTI-ALPS = global/anterior/middle/posterior diffusion along perivascular space index; g/a/m/pBOLD-CSF coupling = the coupling between blood-oxygen-level-dependent signals from global/anterior/middle/posterior cortical gray matter and cerebrospinal fluid signals. *P < 0.05, **P < 0.01, ***P < 0.001.