Table1.
Demographic and neuropsychiatric assessment of patients with bvFTD and health controls (HCs).
| Discovery dataset | Replication datasetc | bvFTDd | HCsd | |||||
|---|---|---|---|---|---|---|---|---|
| bvFTD (N=26) | HCs (N=29) | P value | bvFTD (N=48) | HCs (N=38) | P value | P value | P value | |
| Mean age, y | 63.00 (7.73) | 60.31 (8.31) | 0.221 | 60.72 (5.97) | 60.03 (7.15) | 0.792 | 0.164 | 0.881 |
| Gender, male | 10 (38.46%) | 11 (37.93%) | 0.968 | 33 (64.58%) | 17 (44.74%) | 0.104 | 0.031 | 0.576 |
| Education, y | 10.04 (4.75) | 10.38 (3.91) | 0.771 | 15.58 (3.03) | 16.50 (2.10) | 0.53 | <0.001 | <0.001 |
| ICV (ml) | 1447.69 (152.38) | 1423.52 (103.83) | 0.900 | 1551.02 (159.66) | 1475.12 (166.44) | 0.051 | 0.009 | 0.361 |
| Cortex (ml) | 401.33 (51.39) | 459.69 (33.39) | <0.001 | 395.85 (56.72) | 443.19 (40.61) | <0.001 | 0.684 | 0.036 |
| WML (ml) | 8.16 (6.73) | 3.73 (10.15) | <0.001 | 13.83 (16.68) | 1.70 (3.39) | <0.001 | 0.698 | 0.158 |
| MMSE | 17.65 (6.03) | 28.66 (1.88) | <0.001 | 24.79 (4.31) | 29.26 (0.86) | <0.001 | <0.001 | 0.345 |
| MoCA | 11.28 (6.02) | 25.17 (2.53) | <0.001 | - | - | - | - | - |
| BNT (30a/15bitem) | 20.04 (6.88) | 28.31 (2.07) | <0.001 | 12.01 (3.71) | 14.55 (0.80) | <0.001 | - | - |
| AVLTa/CVLTb-immediate recall | 3.12 (1.93) | 7.84 (1.88) | <0.001 | 4.27 (2.84) | 8.03 (1.20) | <0.001 | - | - |
| AVLTa/CVLTb-delayed recall | 1.73 (2.55) | 8.41 (2.91) | <0.001 | 3.35 (3.07) | 7.63 (1.36) | <0.001 | - | - |
| AVLTa/CVLTb-recognition | 2.24 (3.90) | 11.55 (2.46) | <0.001 | 6.42 (3.34) | 8.21 (2.08) | 0.009 | - | - |
| CDR-SOB | 7.90 (4.68) | - | - | 5.86 (3.12) | - | - | 0.098 | - |
| NPI-Q | 5.96 (4.89) | - | - | 12.77 (6.37) | - | - | <0.001 | - |
| NPI-apathy severity | 1.73 (1.12) | - | - | 1.94 (1.80) | - | - | 0.176 | - |
| NPI-disinhibition severity | 0.5 (0.99) | - | - | 1.50 (1.11) | - | - | <0.001 | - |
| FBI-total | 21.85 (14.12) | - | - | - | - | - | - | - |
| FBI-apathy | 15.65 (9.39) | - | - | - | - | - | - | - |
| FBI-disinhibition | 6.19 (5.95) | - | - | - | - | - | - | - |
Data are presented as mean ± SD or n (%). bvFTD = behavioral variant frontotemporal dementia; HCs = healthy controls; SD = standard deviation; ICV = intracranial volume; MMSE = Mini-Mental State Examination; MoCA = Montreal Cognitive Assessment; BNT = Boston Naming Test; AVLT = Auditory verbal learning test; CVLT = California Verbal Learning Test; CDR = Clinical Dementia Rating score; SOB = sum of boxes; NPI-Q = Neuropsychiatry Inventory Questionnaire; FBI = Frontal Behavioral Inventory.
a
In discovery dataset;
b
in replication dataset;
c
P-values were adjusted for scanning sites;
d
Discovery dataset versus replication dataset.