Table 2.

Between-group comparison of CP, DTI-ALPS, and BOLD-CSF coupling

	Discovery dataset			Replication datasetc			bvFTDd	HCsd
	bvFTD (N=26)	HCs (N=29)	P value	bvFTD (N=48)	HCs (N=38)	P value	P value	P value
CP volume
CP (ml)	1.96 (0.58)	1.22 (0.31)	<0.001/<0.001 a	1.86 (0.36)	1.16 (0.33)	<0.001/<0.001 a	0.412	0.421
CP (ratio of ICV × 103)	1.35 (0.36)	0.85 (0.20)	<0.001/<0.001 a	1.20 (0.21)	0.78 (0.19)	<0.001/<0.001 a	0.033	0.159
DTI-ALPS
aDTI-ALPS	1.25 (0.16)	1.37 (0.12)	0.002/0.015a/0.494b	1.17 (0.10)	1.34 (0.12)	<0.001/<0.001 a /<0.001 b	0.019	0.277
mDTI-ALPS	1.12 (0.11)	1.27 (0.15)	<0.001/<0.001a/0.174b	1.21 (0.11)	1.40 (0.14)	<0.001/<0.001 a /<0.002 b	0.002	<0.001
pDTI-ALPS	1.04 (0.11)	1.09 (0.13)	0.134/0.245a/0.639b	1.08 (0.12)	1.21 (0.14)	<0.001/<0.001a/0.004b	0.098	<0.001
gDTI-ALPS	1.14 (0.10)	1.24 (0.11)	0.001/0.006a/0.509b	1.16 (0.07)	1.31 (0.10)	<0.001/<0.001a/<0.001b	0.353	0.008
BOLD-CSF coupling
aBOLD-CSF	−0.14 (0.20)	−0.27 (0.22)	0.009/0.045 a	−0.08 (0.17)	−0.23 (0.19)	0.001/0.016 a	0.332	0.382
mBOLD-CSF	−0.20 (0.21)	−0.32 (0.20)	0.028/0.060a	−0.13 (0.18)	−0.27 (0.19)	0.003/0.054a	0.157	0.277
pBOLD-CSF	−0.17 (0.19)	−0.32 (0.18)	0.004/0.010 a	−0.17 (0.18)	−0.29 (0.19)	0.014/0.148a	0.996	0.532
gBOLD-CSF	−0.19 (0.20)	−0.31 (0.20)	0.029/0.064a	−0.14 (0.18)	−0.28 (0.19)	0.003/0.047 a	0.264	0.524

Data are presented as mean (SD). bvFTD = behavioral variant frontotemporal dementia; HCs = healthy controls; CP = choroid plexus; ICV = intracranial volume; g/a/m/pDTI-ALPS = global/anterior/middle/posterior diffusion along perivascular space index; g/a/m/pBOLD-CSF coupling = the coupling between blood-oxygen-level-dependent signals from global/anterior/middle/posterior cortical gray matter and cerebrospinal fluid signals.

^aCortical gray matter volume-adjusted P value;

^bCortical gray matter volume-, white matter lesion volume- and intracranial volume-adjusted P value;

^cP-values were adjusted for scanning sites;

^dDiscovery dataset versus replication dataset.