Table 2.

Results of the resting-state functional connectivity analyses of the flocculus. (a) Full factorial results—main and interaction effects, between-group results; (b) regression analysis results

a) Full factorial ANOVA
		L/R	Brain region	k	Peak Z	Peak p	x	y	z
Main effect of group			ns
Main effect of hemisphere			ns
Interaction effect group × hemisphere		L	Precentral gyrus	300	4.54	< 0.001	− 38	2	32
Between-group results
Seed region	Comparison	L/R	Brain region	k	Peak Z	Peak p	x	y	z
Left flocculus	HC > PTSD	L	Supramarginal gyrus/TPJ	1210	4.54	< 0.001	− 56	− 38	40
		L	Angular gyrus	836	4.48	< 0.001	− 34	− 64	46
		L	Superior parietal lobule/IPS/PEF	Subcluster	3.93	< 0.001	− 22	− 62	46
	PTSD > HC		ns
	HC > PTSD + DS	L	Supramarginal gyrus/TPJ	267	3.94	< 0.001	− 56	− 36	40
		R	Precentral gyrus/middle cingulum/PCC	252	3.93	< 0.001	4	− 26	50
		L	Angular gyrus/IPS/PEF	621	3.9	< 0.001	− 34	− 62	44
		L/R	Medial superior frontal gyrus	281	3.63	< 0.001	2	66	22
		L/R	Precuneus	426	3.62	< 0.001	0	− 70	36
	PTSD + DS > HC		ns
	PTSD + DS > PTSD		ns
	PTSD > PTSD + DS		ns
Right flocculus	HC > PTSD		ns
	PTSD > HC		ns
	HC > PTSD + DS		ns
	PTSD + DS > HC		ns
	PTSD + DS > PTSD	R	Hippocampus*	19	3.63	< 0.013*	34	− 8	− 20
	PTSD > PTSD + DS		ns
b) Correlation with symptoms
CAPS tot
Seed region	Correlation	L/R	Brain region	k	Z	p	x	y	z
Left flocculus	Negative correlation	L	Precentral gyrus	4715 (subcluster)	4.42	< 0.001	− 56	12	34
		L	Supramarginal gyrus	subcluster	4.24	< 0.001	− 54	− 32	42
		R	Supramarginal gyrus	376 (subcluster)	4.24	< 0.001	56	− 36	34
MDI Dep/Der	Correlation	L/R	Brain region	k	Z	p	x	y	z
Right flocculus	Positive correlation	R	Vermis V/VI	331	3.93	< 0.001	0	− 60	− 20
		L	Lingual gyrus	244	3.92	< 0.001	− 18	− 68	2
CTQ tot	Correlation	L/R	Brain region	k	Z	p	x	y	z
Left flocculus	Negative correlation	R	Superior frontal gyrus	717	4.58	< 0.001	14	40	42
		L	Superior frontal gyrus	197	3.76	< 0.001	− 14	48	34
		L	Precentral gyrus	300	3.73	< 0.001	− 58	10	30
		L	Superior parietal lobule/angular gyrus	198	3.17	< 0.001	− 28	− 64	40
Right flocculus	Positive correlation	R	Hippocampus*	27	3.62	< 0.014*	26	− 12	− 18
RSDI dep/der	Correlation	L/R	Brain region	k	Z	p	x	y	z
Left flocculus	Negative correlation	R	Medial superior frontal gyrus	202	4.35	< 0.001	10	40	46
		L	Superior parietal lobule	247	3.19	< 0.001	− 22	− 68	46

All results are reported at p < .05 whole-brain corrected threshold. * ROI analysis reports p < .05 FWE-corrected at the peak level within the ROI. Coordinates are reported in the MNI space

Abbreviations: CAPS Clinician Administered PTSD Scale, CTQ Childhood Trauma Questionnaire, HC healthy control group, IPS intraparietal sulcus, k cluster extent, L left hemisphere, MDI Multiscale Dissociation Inventory, ns not significant results, PEF parietal eye field, PTSD post-traumatic stress disorder group, PTSD + DS PTSD dissociative subtype group, R right hemisphere, RSDI Response Script-Driven Imagery scale, TPJ temporo-parietal junction