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. 2023 Nov 18;14:7504. doi: 10.1038/s41467-023-43389-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Schematic illustration of miRNA detection in human plasma samples using the asymmetric CRISPR assay. Illustration was created with BioRender.com. b Estimated target miR-19a concentrations in the bladder patient plasma samples (samples 1–10) and the healthy donor plasma samples (samples 11–15). The Blue dashed line represents the highest target miRNA concentration of healthy donors plus standard deviation. (n = 3, Data are represented as mean ± S.D of three technical replicates.) c Heatmap of the estimated target miR-19a concentrations of the asymmetric CRISPR assay and conventional RT-qPCR assay. d miR-19a expression level analyzed by asymmetric CRISPR (red) and RT-qPCR (black) in bladder patients and healthy donors. The center line represents the median expression level, the bounds of the box indicate the interquartile range, and the whiskers indicate the maximum and minimum values. Source data are provided as a Source Data file.