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. 2023 Nov 18;9:419. doi: 10.1038/s41420-023-01712-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A The analysis of expression levels of 24 ferroptosis-associated genes from GEO datasets (GEO58137). B The expression of iron metabolism-related proteins was detected by Western blot (n = 3). C Intracellular Fe²⁺ was detected after the knockdown of NCOA4 by the FerroOrange probe (1 μM, 30 min) (n = 3). Scale bars, 25 μm. D The expression of SA-β-Gal staining positive cells were ameliorated after knockdown of NCOA4 (n = 3). Scale bars, 100 μm. E The expression of P21, p-H2AX and IL-6 were ameliorated after knockdown of NCOA4 (n = 3). F Immunofluorescence staining of p-H2AX and 8-OhdG. Scale bars, 25 μm. Data are shown as Mean ± SD. *p < 0.05 vs. control group. ^#p < 0.05 vs. TBH group.