Table 1.
FGFR alterations in selected patient-derived xenografts.
| Model | Origin of biopsy | Subtype | FGFR mutations/amplifications | RNA relative overexpression |
|---|---|---|---|---|
| BCX.022 | Primary | IDC | FGFR1 AMP | |
| BCX.011 | Primary | IDC | FGFR1 AMP | |
| BCX.010 | Primary | Metaplastic/ Sarcomatoid | FGFR1 V273M | |
| BCX.066 | Locoregional recurrence | IDC | FGFR2 AMP | |
| BCX.006 | Primary | IDC | FGFR4 AMP | |
| BCX.095 | Primary | IDC | FGFR1 | |
| BCX.051 | Primary | IDC | FGFR1/2 | |
| BCX.080 | Primary | IDC | FGFR3/4 | |
| PDX.007 | Distant metastasis (pleural fluid) | IDC | FGFR2 Y375C | |
| FGFR2 AMP | N/A* |
IDC, invasive ductal carcinoma; AMP, amplification; FGFR, fibroblast growth factor receptor; N/A, not applicable.
*RNAseq data not available.