Table 2.
Demographic and clinical characteristics of patients receiving colistin and polymyxin B
| Parametersa | CMS (n=108) | PMB (n=54) | P |
|---|---|---|---|
| Age (years) | 56.57±16.20 | 58.09±15.83 | 0.572 |
| Gender, male | 74 (68.5) | 42 (77.8) | 0.218 |
| Weight (kg) | 68.79±9.33 | 67.74±10.59 | 0.522 |
| Baseline creatinine clearance (mL/min) | 117.15±88.25 | 89.79±107.31 | 0.086 |
| CCI score | 4.28±2.00 | 3.81±2.14 | 0.178 |
| ICU admission | 60 (55.6) | 40 (74.1) | 0.022 |
| APACHE-II score | 20.87±1.72 | 18.75±3.89 | 0.002 |
| Causative MDR bacteria | |||
| Klebsiella pneumoniae | 55 (50.9) | 32 (59.3) | 0.316 |
| Pseudomonas aeruginosa | 30 (27.8) | 13 (24.1) | 0.615 |
| Acinetobacter baumannii | 18 (16.7) | 8 (14.8) | 0.762 |
| Escherichia coli | 10 (9.3) | 1 (1.9) | 0.077 |
| Other Gram-negative bacteria | 18 (16.7) | 6 (11.1) | 0.348 |
| Type of infection | |||
| Pneumonia | 8 (7.4) | 4 (7.4) | 1.000 |
| Bloodstream infection | 66 (61.1) | 35 (64.8) | 0.774 |
| UTI | 27 (25) | 6 (11.1) | 0.039 |
| Skin and soft-tissue infection | 8 (7.4) | 6 (11.1) | 0.429 |
| Other internal infections | 13 (12) | 3 (5.6) | 0.192 |
| Concomitant nephrotoxic agents | 11 (10.2) | 11 (20.4) | 0.074 |
| Vancomycin | 9 (8.3) | 10 (18.5) | 0.058 |
| Aminoglycosides | 1 (0.9) | 1 (1.8) | 0.605 |
| Furosemide IV | 4 (3.7) | 2 (3.7) | 1.000 |
| Comorbidities* | 80 (74.1) | 38 (70.4) | 0.617 |
| DM | 44 (40.7) | 13 (24.1) | 0.036 |
| Hypertension | 58 (53.7) | 25 (46.3) | 0.505 |
| CAD | 20 (18.5) | 12 (22.2) | 0.595 |
| Malignancy | 22 (20.4) | 9 (16.7) | 0.646 |
| Dyslipidemia | 20 (18.5) | 5 (9.3) | 0.124 |
| AKI | 13 (12) | 3 (5.6) | 0.306 |
| CKD | 4 (3.7) | 6 (11.1) | 0.133 |
| Others | 27 (25) | 14 (25.9) | 0.898 |
*Cumulative percentage of comorbidities exceeds 100%, since a patient can have >1 comorbid condition, aData are presented as mean±SD or n (%). CMS=Colistimethate sodium, PMB=Polymyxin B, CCI=Charlson comorbidity index, APACHE-II=Acute Physiology and Chronic Health Evaluation II, ICU=Intensive care unit, CAD=Coronary artery disease, AKI=Acute kidney injury, CKD=Chronic kidney disease, MDR=Multidrug-resistant, UTI=Urinary tract infection, DM=Diabetes mellitus, SD=Standard deviation