Table 2.

Categories of recurrent high-grade NMIBC included in the CISTO study

Category	Definition
1a. BCG Unresponsive	Persistent or recurrent high-grade NMIBC (stage Tis, Ta, or T1) determined at 6-month evaluation. Patient must have had 5 out of 6 induction BCG instillations and 2 out of 3 maintenance BCG instillations
1b. BCG Unresponsivea	Any stage progression at 3-month evaluation despite 5 out of 6 induction BCG instillations
2. Relapsing	Recurrent high-grade NMIBC more than 6 months after diagnosis. Patient must have had at least 3 out of 6 induction BCG instillations and had a maintenance BCG instillation within the last 6 months
3. No recent BCGa	Had at least 3 of 6 induction BCG instillations at any point in time. Must have had at least one instillation of some type of intravesical agent (induction or maintenance; postop instillation does not apply) or one administration of systemic therapy approved for NMIBC treatment in last 12 months

NMIBC Non-muscle invasive bladder cancer, BCG Bacillus Calmette-Guérin

^aTypically excluded from clinical trials