Table 4.
Combined colon and striatum module association with Thy1-haSyn
| Predictors | Striatum | Colon | Combined | ||||||
| Estimates | CI | p | Estimates | CI | p | Estimates | CI | p | |
| All matched samples (n = 16) | |||||||||
| (Intercept) | 0.72 | 0.50, 0.93 | <0.001 | 0.88 | 0.44, 1.33 | 0.001 | 0.82 | 0.63, 1.02 | <0.001 |
| age | –0.3 | –0.60, 0.00 | 0.051 | –0.15 | –0.75, 0.45 | 0.599 | –0.42 | –0.71, – 0.14 | 0.009 |
| Striatum modules | |||||||||
| royalblue | 0.53 | –0.27, 1.33 | 0.175 | 0.41 | –0.27, 1.08 | 0.204 | |||
| Brain-UPR | –1.41 | –2.25, – 0.58 | 0.003 | –0.73 | –1.67, 0.22 | 0.113 | |||
| Brain-Snca | 0.79 | 0.16, 1.42 | 0.018 | 0.65 | 0.13, 1.17 | 0.021 | |||
| age*Brain-UPR | –1.06 | –2.12, 0.01 | 0.051 | ||||||
| Colon modules | |||||||||
| Gut-ENS | –2.52 | –4.63, – 0.40 | 0.024 | –1.38 | –2.41, – 0.35 | 0.015 | |||
| age* Gut-ENS | 3.17 | 0.04, 6.30 | 0.048 | 1.52 | 0.12, 2.91 | 0.036 | |||
| R2/R2 adjusted | 0.848/0.793 | 0.378/0.222 | 0.940/0.888 | ||||||
| One month (n = 7) | |||||||||
| (Intercept) | 0.73 | 0.37, 1.09 | 0.003 | 0.5 | 0.26, 0.74 | 0.003 | 0.6 | 0.41, 0.79 | 0.001 |
| Brain-UPR | –1.91 | –3.52, – 0.31 | 0.028 | –0.99 | –1.94, – 0.03 | 0.046 | |||
| Gut-proteolysis | 1.7 | 0.82, 2.59 | 0.004 | 1.25 | 0.49, 2.00 | 0.01 | |||
| R2/R2 adjusted | 0.653/0.584 | 0.831/0.797 | 0.945/0.917 | ||||||
Regression model following backwards stepwise regression based on Akaike information criterion (AIC). Thy1-haSyn-associated modules (univariate, unadjusted p < 0.05) were included following assessment for co-linearity. For age-associated modules, age and the age*module interaction effect were included. Analysis included the subset of samples with RNA-seq data from both tissues [n = 10 Thy1-haSyn (4 1 m, 6 3 m), n = 6 WT (3 1 m, 3 3 m)]. This subset was similar to the full sample with regard to Thy1-haSyn-associated modules (Supplementary Tables 9 and 10). CI, confidence interval.