Table 3.

Description of DEPs

Protein_ID	Description	Definition	Function	Day2/saline	Day15/saline
Q641Y7	8-oxo-dGDP phosphatase NUDT18			0.574389373	0.608172558
D4A7X5	Protein Ppm1k			1.202828351	0.699477037
Q8R4T5	General receptor for phosphoinositide 1-associated scaffold protein			1.299988943	0.714486298
D4ADD7	Glutaredoxin 5 homologue (S. cerevisiae)			1.413717159	0.728687695
A0A0G2JTL7	Protein Ankib1			0.371929128	0.436264122
M0RCA3	Protein Zfpl1			0.65654354	0.715790973
D3ZGY4	Glyceraldehyde-3-phosphate dehydrogenase	Glyceraldehyde 3-phosphate dehydrogenase	Carbon metabolism Alzheimer’s disease Biosynthesis of amino acids HIF-1 signalling pathway Glycolysis/Gluconeogenesis	1.837826416	0.704589896
M0R6D6	Uncharacterised protein	Cofilin	Pertussis Axon guidance Fc gamma R-mediated phagocytosis Regulation of actin cytoskeleton	1.94767651	0.667735825
F1M378	Protein unc-13 homologue A	Protein unc-13 A/B/C	Synaptic vesicle cycle	1.265864023	0.737587245
Q8R462	Glutamate transporter splice variant GLT1a	Solute carrier family 1 (glial high affinity glutamate transporter), member 2	Amyotrophic lateral sclerosis (ALS) Glutamatergic synapse	2.214674084	0.401431656
D4A2Z8	DEAH (Asp-Glu-Ala-His) box polypeptide 36	ATP-dependent RNA helicase DHX36	RNA degradation	0.809824354	0.805031089
Q3KRE3	Guanine nucleotide-binding protein subunit gamma	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	Cholinergic synapse Morphine addiction PI3K-Akt signalling pathway Relaxin signalling pathway Circadian entrainment GABAergic synapse Alcoholism Apelin signalling pathway Retrograde endocannabinoid signalling Chemokine signalling pathway Dopaminergic synapse Glutamatergic synapse Pathways in cancer Ras signalling pathway Serotonergic synapse Kaposi’s sarcoma-associated herpesvirus infection	1.294581532	0.795495921
Q6IFV3	Keratin, type I cytoskeletal 15	type I keratin, acidic	Staphylococcus aureus infection	0.603158306	0.726730723